Other Publication Details
Mandatory Fields
Reviews
Muimhneachain, EO;Reen, FJ;O'Gara, F;McGlacken, GP
2018
January
Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections
Validated
1
Optional Fields
QUORUM-SENSING INHIBITORS GRAM-NEGATIVE BACTERIA TO-CELL COMMUNICATION QUINOLONE SIGNAL BIOFILM FORMATION CYSTIC-FIBROSIS BURKHOLDERIA-PSEUDOMALLEI BIOLOGICAL EVALUATION C-3 POSITION BAD BUGS
The emergence of antibiotic resistance coupled with the lack of investment by pharmaceutical companies necessitates a new look at how we tackle bacterial infections. An intriguing tactic is the interruption of bacterial communication systems. This non-biocidal approach would circumvent the evolutionary pressure on bacteria to mutate and develop resistance. In many pathogenic microorganisms, communication systems, collectively termed quorum sensing (QS), have been observed to control a number of bacterial behaviours including expression of virulence factors and the development of biofilms. QS signalling molecules and their biomimetics, therefore, represent a rational target for the disruption of cooperative behaviour and thus the development of novel antimicrobial strategies. Herein we review recent developments towards the interference of Pseudomonas aeruginosa QS using signalling molecules and their mimetics.
CAMBRIDGE
ROYAL SOC CHEMISTRY
1477-0520
169
179
10.1039/c7ob02395b
Grant Details