Peer-Reviewed Journal Details
Mandatory Fields
Cano, Rafael; Mackey, Katrina; McGlacken, Gerard P.
Catalysis Science & Technology
Recent advances in manganese-catalysed CH activation: scope and mechanism
Optional Fields
Critical raw materials C-H activation Earth Abundant Metals (EAMs) Manganese-based catalytic systems.
As a synthetic methodology, CH activation represents a complimentary protocol to traditional cross-couplings such as the SuzukiMiyaura and Stille reactions, by avoiding the extra synthetic steps required to install activating groups. CH activation also often avoids the production of waste associated with B, Sn, halide etc. Pd-catalysed transformations have been most prominent in the CH activation realm. However, as a society we are over-reliant on transitional metals, cost is increasing, and the accessible supply is dwindling. One potential solution is to develop chemistry using Earth Abundant Metals (EAMs). Manganese (Mn), in particular, demonstrates great promise. Since the publication of an excellent review by Ackermann in 2016 (ACS Catal. 2016, 6, 37433652), there has been a flurry of reports on Mn-catalysed CH activation. We report here an overview of approximately 30 new papers, which include a number of notable advances since April 2016.
Grant Details
Science Foundation Ireland
(SFI/12/IP/1315 and SFI/12/RC/2275) and the Synthesis and Solid State Pharmaceutical Centre (SSPC).