Peer-Reviewed Journal Details
Mandatory Fields
Crowley, Daniel C.; Lynch, Denis; Maguire, Anita R.
The Journal of Organic Chemistry
Copper mediated, heterogeneous, enantioselective intramolecular Buchner reactions of a-diazoketones using continuous flow processing
In Press
WOS: 16 ()
Optional Fields
Enantioselective intramolecular Buchner reactions of a-diazoketones can be effected using heterogeneous copper-bis(oxazoline) catalysts in batch or using continuous flow processing in up to 83% ee. The catalyst can be reused up to 7 times without loss of activity. For a-diazoketones 3 and 4, the enantioselection achieved in flow with the immobilized catalyst was comparable with the standard homogeneous catalyzed process.
Grant Details