Peer-Reviewed Journal Details
Mandatory Fields
Henze, Laura J.; Griffin, Brendan T.; Christiansen, Martin; Bundgaard, Christoffer; Langguth, Peter; Holm, Rene
European Journal of Pharmaceutical Sciences
Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide
In Press
Optional Fields
Gastric emptying Mini-pigs Metoclopramide Fasted state Fed state
The present study investigated the gastric emptying rate in Göttingen minipigs pre- and post-prandial and evaluated the effect of metoclopramide on the same parameter, using paracetamol as an absorption marker. The pharmacokinetic evaluation of the obtained plasma concentration data for paracetamol demonstrated that the fastest gastric emptying rate was observed in the animals that were allowed access to normal pig food. There was no significant difference in the stomach emptying rate observed between fasted and fed minipigs, when fed either with a FDA standard breakfast or a nutritional energy drink. Pre-dosing minipigs with metoclopramide (0.2 or 0.4¿mg/kg) did not demonstrate any effect on gastric emptying in either the fasted or fed state. The data in the present study demonstrated a relatively prolonged gastric emptying rate in mini-pigs both in the fasted and fed state, hence when conducting pharmacokinetic studies using mini-pigs, this should be taken into account in planning the plasma sampling time points. Further, as no difference could be observe in gastric emptying rate as a function of food the data also suggest that the Göttingen minipigs seems less suited to predict for food effect studies than other species.
Grant Details
Horizon 2020
Horizon 2020 Marie Sklodowska-Curie Innovative Training Networks programme under grant agreement No. 674909.