Other Publication Details
Mandatory Fields
Reviews
Cano, R;Mackey, K;McGlacken, GP
2018
March
Recent advances in manganese-catalysed C-H activation: scope and mechanism
Validated
1
WOS: 57 ()
Optional Fields
NITROGEN-ATOM-TRANSFER BOND ACTIVATION DIRECT ARYLATION ORTHO-FUNCTIONALIZATION ARYL-KETONES FLUORIDE-ION ALKYNES COMPLEXES FLUORINATION ALLYLATION
As a synthetic methodology, C-H activation represents a complimentary protocol to traditional cross-couplings such as the Suzuki-Miyaura and Stille reactions, by avoiding the extra synthetic steps required to install activating groups. C-H activation also often avoids the production of waste associated with B, Sn, halide etc. Pd-catalysed transformations have been most prominent in the C-H activation realm. However, as a society we are over-reliant on transitional metals, cost is increasing, and the accessible supply is dwindling. One potential solution is to develop chemistry using Earth Abundant Metals (EAMs). Manganese (Mn), in particular, demonstrates great promise. Since the publication of an excellent review by Ackermann in 2016 (ACS Catal. 2016, 6, 3743-3652), there has been a flurry of reports on Mn-catalysed C-H activation. We report here an overview of approximately 30 new papers, which include a number of notable advances since April 2016.
CAMBRIDGE
ROYAL SOC CHEMISTRY
2044-4753
1251
1266
10.1039/c7cy02514a
Grant Details