Peer-Reviewed Journal Details
Mandatory Fields
Maguire, Anita R.; Shiely, Amy; Clarke, Leslie Ann; Flynn, Chris; Buckley, Aoife; Ford, Alan; Lawrence, Simon
2018
March
European Journal of Organic Chemistry
Substrate and catalyst effects in the enantioselective copper catalysed C-H insertion reactions of a-diazo--oxo sulfones
Validated
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Optional Fields
Asymmetric C-H insertion Copper catalysis α-Diazocarbonyl compounds α-Diazo-β-oxo sulfones bis(oxazoline) ligands
Excellent enantioselectivities of up to 98% ee are achieved employing the copper‐bis(oxazoline)‐NaBARF catalyst system in the C‐H insertion reactions of α‐diazo‐β‐oxo sulfones. The influence of variation of the bis(oxazoline) ligand, copper salt, additive and substrate on both the efficiency and the enantioselectivities of these intramolecular C‐H insertion reactions has been explored. Optimum enantioselectivities are achieved with the phenyl and diphenyl ligands across the substrate series.
1099-0690
10.1002/ejoc.201800077
Grant Details