O'Neill, S,O'Keeffe, S,Harrington, F,Maguire, AR;

2009

September

Synlett

Enhancement of Enantioselection in the Copper-Catalysed Intramolecular Buchner Reaction by Variation of the Counterion

Validated

()

intramolecular Buchner reaction carbenes alpha-diazoketones copper bis(oxazoline) catalyst asymmetric catalysis ASYMMETRIC CYCLOPROPANATION H BONDS ALPHA-DIAZOKETONES INSERTION COMPLEXES CARBENOIDS SOLVENT REAGENT WATER

2312

2314

Variation of the enantioselection of the copper-catalysed intramolecular Buchner reaction of diazoketones with the nature of the counterion is reported significantly the presence of the non-coordinating BARF anion leads to enhanced enantioselectivities when the aryl group bears electron-withdrawing halo substituents.

DOI 10.1055/s-0029-1217709