Clarke, G,O'Mahony, SM,Hennessy, AA,Ross, P,Stanton, C,Cryan, JF,Dinan, TG;

2009

May

Behavioural Brain Research

Chain reactions: Early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood

Validated

()

Stress Animal model Maternal separation Arachidonic acid Depression Gas chromatography IRRITABLE-BOWEL-SYNDROME MOOD DISORDERS MESSENGER-RNA ANIMAL-MODELS RATS DEPRESSION DEPRIVATION ILLNESSES RODENTS

205

319

321

The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders. (C) 2009 Elsevier B.V. All rights reserved.

DOI 10.1016/j.bbr.2009.07.008