Peer-Reviewed Journal Details
Mandatory Fields
O'Leary, P,Maguire, AR;
2009
September
Arkivoc
Efficient construction of novel carbocyclic frameworks via intramolecular aromatic addition of diazoketones followed by Diels-Alder cycloaddition
Validated
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Optional Fields
Rhodium catalysis diazoketone Diels-Alder stereoselective azulenone DIAZOMETHYL KETONES BUCHNER REACTION CARBENOIDS PRODUCTS INSERTION
130
151
Rhodium catalysed intramolecular aromatic additions of diazoketones followed by Diels-Alder cycloadditions with carbon-based dienophiles leads in a highly stereoselective manner to polycyclic frameworks containing eight stereogenic centres completely controlled by the single stereocentre present in the diazoketone precursor. These cycloadditions provide interesting mechanistic insight into a dynamic equilibrium in methoxy-substituted azulenones.
Grant Details