Peer-Reviewed Journal Details
Mandatory Fields
Paulo MC, Andrade AM, Andrade ML, Morais MG, Kiely M, Parra D, Martinez JA, Thorsdottir I, Bandarra NM.
Nutrition Metabolism and Cardiovascular Diseases
Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects
Optional Fields
Fish diet n-3 fatty acids Cardiovascular disease Soluble intercellular adhesion molecule-1 Soluble vascular adhesion molecule-1 Healthy subjects CORONARY-ARTERY-DISEASE ALPHA-LINOLENIC ACID FISH CONSUMPTION HEART-DISEASE ENDOTHELIAL-CELLS IMMUNE FUNCTION OBESE WOMEN ATHEROSCLEROSIS OMEGA-3-FATTY-ACIDS EXPRESSION
Background and aim: Serum levels of soluble cellular adhesion molecules (CAMS) and blood lipid parameters have been used as markers of inflammatory processes associated with cardiovascular disease (CVD) events. The present study evaluated the effects of the intake of n-3 polyunsaturated fatty acids (PUFAs) in fish and fish oil within energy-restricted diets, on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1).Methods and results: Two hundred and seventy-five healthy European subjects aged between 20 and 40 years, were randomized to one of four hypocaloric dietary groups: control (sunflower oil capsules, no seafood), lean fish (3 x 150 g portions of cod/week), fatty fish (3 x 150 g portions of salmon/week), fish oil ((docosahexaenoic acid (DHA) -+- eicosapentaenoic acid (EPA) capsules, no seafood)). Diets rich in lean fish significantly decreased ICAM-1 levels, around 5% from baseline to endpoint (p < 0.05), and had no effect on VCAM-1 levels. No significant differences were observed in sICAM-1 levels after the intervention with fatty fish or fish oils. On the other hand, these two seafood based diets were responsible for a significant increase of VCAM-1 levels [fatty fish; 16.1% and fish oil; 21.9%] respectively (p < 0.05).Conclusions: CAMS as inflammatory biomarkers in young and healthy subjects are not conclusive for the evaluation of CVD risk. Hypocaloric fish diets had a different effect on CAMS,
DOI 10.1016/j.numecd.2007.11.007
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