Peer-Reviewed Journal Details
Mandatory Fields
Quigley, EMM;
2007
July
Gastroenterology Clinics of North America
Bacteria: A new player in gastrointestinal motility disorders-infections, bacterial overgrowth, and Probiotics
Validated
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Optional Fields
IRRITABLE-BOWEL-SYNDROME INDUCED VISCERAL HYPERSENSITIVITY RANDOMIZED CONTROLLED-TRIAL SMALL-INTESTINAL MOTILITY DISABLED OLDER-ADULTS NECROSIS-FACTOR-ALPHA DOUBLE-BLIND IMMUNE ACTIVATION REDUCES SYMPTOMS HEALTHY CONTROLS
36
735
Irritable bowel syndrome (IBS) may result from a dysfunctional interaction between the indigenous flora and the intestinal mucosa, which in turn leads to immune activation in the colonic mucosa. Some propose that bacterial overgrowth is a common causative factor in the pathogenesis of symptoms in IBS; others point to evidence suggesting that the cause stems from more subtle qualitative changes in the colonic flora. Bacterial overgrowth will probably prove not to be a major factor in what will eventually be defined as IBS. Nevertheless, short-term therapy with either antibiotics or probiotics seems to reduce symptoms among IBS patients. However, in the long term, safety issues will favor the probiotic approach; results of long-term studies with these agents are eagerly awaited.
DOI 10.1016/j.gtc.2007.07.012
Grant Details