Peer-Reviewed Journal Details
Mandatory Fields
Abbas, A., Adams, C., Scully, N., Glennon., J., and O'Gara, F.;
2007
July
Fems Microbiology Letters
A role for TonB1 in biofilm formation and quorum sensing in Pseudomonas aeruginosa.
Published
()
Optional Fields
TonB1 biofilm motility quorum sensing TO-CELL SIGNALS TWITCHING MOTILITY MULTIDRUG-RESISTANCE ENERGY TRANSDUCTION BACTERIAL BIOFILM ESCHERICHIA-COLI IRON ACQUISITION OUTER-MEMBRANE IV PILI PROTEIN
274
2
269
278
This study revealed that a Pseudomonas aeruginosa tonB1 mutant was unable to produce a mature biofilm and showed reduced swarming and twitching motilities compared with the parent strain. The tonB1 mutant was also found to produce significantly lower cell-free and cell-associated levels of the quorum sensing (QS) signal molecule 3-oxo-C12-AHL. Altered biofilm and motility phenotypes were restored to wildtype with the addition of exogenous N-acylhomoserine lactones. These functions were independent of the role of TonB1 in iron uptake. This is the first time that a link has been established between TonB1 activity and QS.
DOI 10.1111/j.1574-6968.2007.00845.x
Grant Details