Kelly, P,Lawrence, SE,Maguire, AR;

2007

January

Synlett

Chemoselectivity and enantioselectivity in copper-catalysed oxidation of aryl benzyl sulfides

Validated

()

asymmetric catalysis oxidation copper sulfoxides Schiff bases AQUEOUS HYDROGEN-PEROXIDE EFFICIENT ASYMMETRIC OXIDATION CHIRAL SCHIFF-BASES KINETIC RESOLUTION ORGANIC SULFIDES SULFOXIDES COMPLEXES ROUTE BIOTRANSFORMATION HYDROPEROXIDE

1501

1506

Enantioselective copper-catalysed oxidation of aryl benzyl sulfides yields enantioenriched sulfoxides (up to 81% ee) in modest yield. This is the highest enantioselectivity reported using a copper catalyst in enantioselective sulfide oxidation. The enhancement of the enantioselectivity of this method through the use of additives is discussed.

DOI 10.1055/s-2007-982555