Peer-Reviewed Journal Details
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Gilman, J,Shanahan, F,Cashman, KD;
2006
January
Alimentary Pharmacology And Therapeutics
Altered levels of biochemical indices of bone turnover and bone-related vitamins in patients with Crohn's disease and ulcerative colitis
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Optional Fields
INFLAMMATORY-BOWEL-DISEASE MINERAL DENSITY D DEFICIENCY NUTRITIONAL-STATUS K DEFICIENCY I COLLAGEN METABOLISM RISK OSTEOPOROSIS MARKERS
23
1007
1016
Background The pathogenesis of inflammatory bowel disease-associated osteopenia may be related to pathological rates of bone turnover; however, the literature shows mixed results.Aim To compare bone biomarkers in inflammatory bowel disease patients (Crohn's disease: n = 68, and ulcerative colitis: n = 32, separately) with age- and sex-matched healthy controls.Subjects Patients and controls were recruited from Cork University Hospital and Cork City area, respectively.Results Relative to that in their respective controls, Crohn's disease (n = 47) and ulcerative colitis (n = 26) patients (i.e. excluding supplement users) had significantly (P < 0.05-0.001) higher serum undercarboxylated osteocalcin (by 27% and 63%, respectively) and bone-specific alkaline phosphatase (by 15% and 21%, respectively) and urinary Type I collagen cross-linked N-telopeptides concentrations (by 87% and 112%, respectively). Relative to that in their respective controls, Crohn's disease and ulcerative colitis patients had significantly (P < 0.01) lower serum total osteocalcin (by 20% and 42%, respectively) and 25-hydroxyvitamin D (by 37% and 42%, respectively), while serum parathyroid hormone levels were similar. In the combined patient group (n = 100), undercarboxylated osteocalcin was positively associated with bone markers.Conclusions Both Crohn's disease and ulcerative colitis patients have altered bone turnover relative to that in healthy controls.
DOI 10.1111/j.1365-2036.2006.02835.x
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