O'Flaherty, S,Coffey, A,Meaney, W,Fitzgerald, GF,Ross, RP;

2005

May

Journal of Bacteriology

The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant Staphylococci, including methicillin-resistant Staphylococcus aureus

Validated

()

IDENTIFICATION ENDOLYSIN ENZYME AGENT HOLIN GENE

187

7161

7164

This study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis. Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus. LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci.

DOI 10.1128/JB.187.20.7161-7164.2005