Peer-Reviewed Journal Details
Mandatory Fields
Harrington, M,Bennett, T,Jakobsen, J,Ovesen, L,Brot, C,Flynn, A,Cashman, KD;
European Journal of Clinical Nutrition
Effect of a high-protein, high-salt diet on calcium and bone metabolism in postmenopausal women stratified by hormone replacement therapy use
Optional Fields
sodium protein bone metabolism HRT postmenopausal women SODIUM INTAKE EXCRETION RESORPTION ABSORPTION ESTROGEN
The objective of this study was to investigate the influence of a high-sodium, high-protein diet on bone metabolism in postmenopausal women ( aged 49 - 60 y) stratified by hormone replacement therapy (HRT) use. In a crossover trial, 18 women (n = 8 HRT users (+HRT) and n = 10 nonusers (-HRT)) were randomly assigned to a diet high in protein ( 90 g/day) and sodium (180 mmol/day) ( calciuric diet) or a diet moderate in protein ( 70 g/day) and low in sodium ( 65 mmol/day) for 4 weeks followed by crossover to alternative dietary regimen for a further 4 weeks. The calciuric diet significantly (P<0.05) increased urinary sodium, calcium and nitrogen in both groups. While the calciuric diet increased urinary N-telopeptide crosslinks of collagen ( by &SIM;25%, P = 0.003) in the - HRT group, it had no effect in the +HRT group. It appears that postmenopausal HRT use attenuates the increase in a marker of bone resorption associated with a calciuric diet.
DOI 10.1038/sj.ejcn.1601983
Grant Details