Peer-Reviewed Journal Details
Mandatory Fields
Dinan, TG,O'Brien, S,Lavelle, E,Scott, LV;
2004
January
International Journal of Psychological Medicine
Further neuroendocrine evidence of enhanced vasopressin V-3 receptor responses in melancholic depression
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Optional Fields
CORTICOTROPIN-RELEASING HORMONE PITUITARY-ADRENAL AXIS MAJOR DEPRESSION HEALTHY-SUBJECTS GLUCOCORTICOIDS PATHOPHYSIOLOGY DISORDERS INCREASE STRESS PLASMA
34
169
172
Background. In situations of chronic stress vasopressin plays an important role in regulating the hypothalamic-pituitary-adrenal axis. The aim of the current study was to investigate the role of anterior pituitary vasopressin V-3 receptors in maintaining the hypercortisolism seen in melancholic depression.Method. Fourteen patients with major depression and 14 age- and sex-matched healthy comparison subjects were recruited. Desmopressin (ddAVP) 10 mug was given intravenously and ACTH and cortisol release was monitored for 120 min.Results. The mean +/- S.E.M. ACTH response in the depressives was 28(.)4 +/- 4(.)3 ng/l and in the healthy subjects was 18(.)8 +/- 4(.)9 ng/l (P = 0(.)04). The mean +/- S.E.M. cortisol response in the depressives was 261(.)8 +/- 46(.)5 nmol/l and in the healthy subjects was 107(.)3 +/- 26(.)1 nmol/l (P < 0(.)01).Conclusions. Patients with major depression have augmented ACTH and cortisol responses to desmopressin indicating enhanced V-3 responsivity.
DOI 10.1017/S0033291703001004
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