Peer-Reviewed Journal Details
Mandatory Fields
Sabharwal, R,Coote, JH,Johns, EJ,Egginton, S;
2004
April
Journal of Physiology-London
Effect of hypothermia on baroreflex control of heart rate and renal sympathetic nerve activity in anaesthetized rats
Validated
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Optional Fields
MODERATE HYPOTHERMIA BARORECEPTOR REFLEX COLD-ACCLIMATION ANESTHESIA SYSTEM RESPONSES PATHOPHYSIOLOGY HYPERTENSION BRADYCARDIA TEMPERATURE
557
247
259
The present study investigated the effect of acute hypothermia on baroreflex control of heart rate (HR) and renal sympathetic nerve activity (RSNA) by generating baroreflex logistic function curves, using bolus doses of phenylephrine and sodium nitroprusside, in anaesthetized male Wistar rats at a core temperature (T-b) of 37degreesC, during acute severe hypothermia at T-b = 25degreesC and on rewarming to 37degreesC. Comparisons were made between rats without (euthermic, n = 6) and with (acclimated, n = 7) prior exposure to lower ambient temperatures and shorter photoperiod, simulating adaptation to winter conditions. In both groups of rats, acute hypothermia to T-b = 25degreesC shifted the baroreflex-RSNA curve slightly leftwards and downwards with decreases in the setpoint pressure and maximal gain, whereas it markedly impaired the baroreflex-HR curve characterized by decreases in response range by similar to90% (P < 0.001), minimum response by, similar to10% (P < 0.05) and maximum gain by similar to95% (P < 0.001), from that at T-b = 37degreesC. All parameters were restored to precooling levels on rewarming. Electrical stimulation of cardiac vagal efferents induced a voltage-related bradycardia, the magnitude of which was partially reduced during acute hypothermia, and there was a significant prolongation of the electrocardiogram intervals indicating a delay in cardiac conduction. Mild suppression of baroreflex control of RSNA could contribute to hypothermic hypotension and may primarily reflect an effect of T-b on central drive. The marked attenuation of the baroreflex control of HR during hypothermia was likely to be due to an impairment of both the central and peripheral components of the reflex arc. Baroreflex control of RSNA and HR was similar between both groups of rats, which implied that the control was non-adaptive on chronic cold exposure.
DOI 10.1113/jphysiol.2003.059444
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