McDermott, M., Hsu, C., Molloy, M.G., Mulcahy, B., Phelan, M., Shanahan, F., O'Gara, F., Adams, C., Rubin, L.A., Clegg, D.O., Husebye, D., Amos, C.I., Ward, R.H., and Kastner, D.L. ;

1995

February

Journal of Autoimmunity

Non-linkage of a T-cell receptor Gamma chain microsatellite (D7S485) to rheumatoid arthritis in multiplex families.

Published

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SYNOVIAL-FLUID DELTA-CELLS BETA-GENE LYMPHOCYTES SCLEROSIS LOCUS SUSCEPTIBILITY POPULATION BLOOD MAP

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A highly informative microsatellite marker, D7S485, from the T-cell receptor gamma (TCRG) locus, has been used to study segregation of TCRG genes in 26 multiplex rheumatoid arthritis (RA) families. We used the sib-pair method to assess excess identity-by-descent sharing among affected members in these families and the LINKAGE package of programs was used to calculate two-point lod scores far the D7S485 marker. There was no evidence for segregation of TCRG genes with RA in affected siblings and significantly negative lad scores were obtained from Linkage analyses using bath autosomal dominant and recessive models of inheritance.