Peer-Reviewed Journal Details
Mandatory Fields
Jeevan, R.; Browne, John P.; Gulliver-Clarke, C.; Pereira, J.; Caddy, C. M.; van der Meulen, J. H. P.; Cromwell, D. A.
2017
February
British Journal of Surgery
Association between age and access to immediate breast reconstruction in women undergoing mastectomy for breast cancer
Validated
Optional Fields
Immediate breast reconstruction Reconstructive decision-making Multivariable logistic regression Tumour burden Planned radiotherapy Performance status
104
5
555
561
Background: National guidelines state that patients with breast cancer undergoing mastectomy in England should be offered immediate breast reconstruction (IR), unless precluded by their fitness for surgery or the need for adjuvant therapies. Methods: A national study investigated factors that influenced clinicians' decision to offer IR, and collected data on case mix, operative procedures and reconstructive decision‐making among women with breast cancer having a mastectomy with or without IR in the English National Health Service between 1 January 2008 and 31 March 2009. Multivariable logistic regression was used to examine the relationship between whether or not women were offered IR and their characteristics (tumour burden, functional status, planned radiotherapy, planned chemotherapy, perioperative fitness, obesity, smoking status and age). Results: Of 13 225 women, 6458 (488 per cent) were offered IR. Among factors the guidelines highlighted as relevant to decision‐making, the three most strongly associated with the likelihood of an offer were tumour burden, planned radiotherapy and performance status. Depending on the combination of their values, the probability of an IR offer ranged from 74 to 851 per cent. A regression model that included all available factors discriminated well between whether or not women were offered IR (c‐statistic 0773), but revealed that increasing age was associated with a fall in the probability of an IR offer beyond that expected from older patients' tumour and co‐morbidity characteristics. Conclusion: Clinicians are broadly following guidance on the offer of IR, except with respect to patients' age.
https://onlinelibrary.wiley.com/doi/abs/10.1002/bjs.10453
10.1002/bjs.10453
Grant Details