Peer-Reviewed Journal Details
Mandatory Fields
Sabharwal R, Coote JH, Johns EJ, Egginton S;
2004
May
The Journal of Physiology
Effect of hypothermia on baroreflex control of heart rate and renal sympathetic nerve activity in anaesthetized rats.
Validated
WOS: 22 ()
Optional Fields
557
Pt 1
247
259
The present study investigated the effect of acute hypothermia on baroreflex control of heart rate (HR) and renal sympathetic nerve activity (RSNA) by generating baroreflex logistic function curves, using bolus doses of phenylephrine and sodium nitroprusside, in anaesthetized male Wistar rats at a core temperature (T(b)) of 37 degrees C, during acute severe hypothermia at T(b)= 25 degrees C and on rewarming to 37 degrees C. Comparisons were made between rats without (euthermic, n= 6) and with (acclimated, n= 7) prior exposure to lower ambient temperatures and shorter photoperiod, simulating adaptation to winter conditions. In both groups of rats, acute hypothermia to T(b)= 25 degrees C shifted the baroreflex-RSNA curve slightly leftwards and downwards with decreases in the setpoint pressure and maximal gain, whereas it markedly impaired the baroreflex-HR curve characterized by decreases in response range by approximately 90% (P < 0.001), minimum response by approximately 10% (P < 0.05) and maximum gain by approximately 95% (P < 0.001), from that at T(b)= 37 degrees C. All parameters were restored to precooling levels on rewarming. Electrical stimulation of cardiac vagal efferents induced a voltage-related bradycardia, the magnitude of which was partially reduced during acute hypothermia, and there was a significant prolongation of the electrocardiogram intervals indicating a delay in cardiac conduction. Mild suppression of baroreflex control of RSNA could contribute to hypothermic hypotension and may primarily reflect an effect of T(b) on central drive. The marked attenuation of the baroreflex control of HR during hypothermia was likely to be due to an impairment of both the central and peripheral components of the reflex arc. Baroreflex control of RSNA and HR was similar between both groups of rats, which implied that the control was non-adaptive on chronic cold exposure.
10.1113/jphysiol.2003.059444
Grant Details