Kumar, VP; Gupta, MK; Horgan, C; O'Sullivan, TP

2018

May

Tetrahedron Letters

Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction

Validated

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DE-NOVO SYNTHESIS FATTY-ACIDS ISOMERIZATION BACTERIA THERAPY

59

2193

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The development of a concise synthesis of the quorum sensing molecule Diffusible Signal Factor is described. This route exploits an alkyne zipper reaction to form a key terminal alkyne intermediate. The chemistry outlined here may also be applied to the preparation of cis-unsaturated analogues of Diffusible Signal Factor. (C) 2018 Elsevier Ltd. All rights reserved.

OXFORD

0040-4039

10.1016/j.tetlet.2018.04.071