Peer-Reviewed Journal Details
Mandatory Fields
Riordan, DO;Aubert, CE;Walsh, KA;Van Dorland, A;Rodondi, N;Du Puy, RS;Poortvliet, RKE;Gussekloo, J;Sinnott, C;Byrne, S;Galvin, R;Jukema, JW;Mooijaart, SP;Baumgartner, C;McCarthy, V;Walsh, EK;Collet, TH;Dekkers, OM;Blum, MR;Kearney, PM
2018
March
Bmj Open
Prevalence and distribution of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants.
Validated
Optional Fields
POTENTIALLY INAPPROPRIATE PRESCRIPTIONS DWELLING OLDER-ADULTS STOPP SCREENING TOOL STOPP/START CRITERIA ELDERLY POPULATION CONTROLLED-TRIAL COST OUTCOMES PEOPLE POLYPHARMACY PREVENTION
8
Obejective estimate and compare the prevalence and type of potentially inappropriate prescribing (P|P)and potential prescribing omissions (PP0o) among community dwelling older adults(>= 65 years) enrolled to a clinical trial in three European countries. Design A secondary analysis of the Thyroid Hormone Replacement for Sokdinica| Hypothyroidism Trial daNexet. Participants Aoubuet of48/80 PIP and 22/34PPOe indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors toRight Treatment (STOPP/START)V2 criteria were applied b p/oxchkod medication data for 532/737 trial participants in Ireland, Switzerland and the Netherlands. Rouu|1a The overall prevalence of PIP was lower in the Irish participants (8.7%) compared with the Swiss (16.7%) and Dutch (12.5%) participants (P=0.15)and was trot statistically significant. The overall prevalence of PP0s was appmximately one-quarter in the Swiss (25.3%) and Dutch (24%) participants and lower inthe Irish (14%) participants (P<0.04) and the difference was statistically significant. The hypnotic 7-drugs were Ne most frequent PIP irish participants, (3.5% n=4). while d was non -steroidal anti-inflammatory drug and nxd anticoagulant combination, ou|fonylumao with o long duration of action, and benzodiazopineo (all 4.3%.n=7)in Swiss, and benzodiozepineo(7]%. o=18)io Dutch participants. The most frequent PP0s in Irish participants were vitamin D and calcium in osteoporosis (3.5% , n=4).In the Swiss and Dutch participants, they were bone antiresorptive/anabolic therapy in osteoporosis (9.9%. n=16, 8.6%, n=22) respectively. The odds of any PIP ukor adjusting for age, sex, multimorbidity and polypharmacy were (adjusted OR (aOR) (95%Cl 1.33 to 6.05.P<0.01) for Swiss participants and aOR1.74 (95% Cl 0.79 to 3.85. P=O.17)for Dutch participants compared with Irish participants. The odds of any PPOs were aOR 2.48 (95% Cl 1.27 to 4.85 , p < 0.002) for Swiss participants and a0R 2.10 (95%Cl 111 to 3.90.P=002) for Dutch participants compared with Irish participants. Conclusions This study has estimated and compared the prevalence arid type of PIP arid PP0s among gthiumhnrt communitity-dwelling older people. it demonstrated significant difference in the prevalence ofPPUobetween the three populations. Further research is urgently needed into the impact of system level factors aothis has important implications for patient safety, helthcare provision and economic costs.
LONDON
2044-6055
10.1136/bmjopen-2017-019003
Grant Details