Peer-Reviewed Journal Details
Mandatory Fields
Prendergast, AM;Zhang, ZH;Lin, ZY;McGlacken, GP
2018
May
Dalton Transactions
Mechanistic studies on the palladium-catalyzed cross-dehydrogenative coupling of 4-phenoxy-2-coumarins: experimental and computational insights
Validated
WOS: 2 ()
Optional Fields
METALATION-DEPROTONATION MECHANISM PROTON-ABSTRACTION MECHANISM C-H ACTIVATION DIRECT ARYLATION INTRAMOLECULAR ARYLATION GREEN CHEMISTRY COUMARINS COORDINATION ACCESS ARENES
47
6049
6053
Delineating the mechanistic features of C-H activation in aryl-heteroaryl coupling is an important step in the design of selective, catalytic processes. Herein we use the intramolecular dehydrogenative coupling of 4-phenoxy-2-coumarins as a model study. Computational results and experimental studies suggest that CMD is operative in the cleavage of both C-H bonds, and that the heteroaryl C-H is cleaved initially.
CAMBRIDGE
1477-9226
10.1039/c8dt00842f
Grant Details