Peer-Reviewed Journal Details
Mandatory Fields
Scanlan PD;
2017
August
Trends In Microbiology
Bacteria-Bacteriophage Coevolution in the Human Gut: Implications for Microbial Diversity and Functionality.
Validated
Optional Fields
25
8
Antagonistic coevolution (AC) between bacteria and bacteriophages plays a key role in driving and maintaining microbial diversity. Consequently, AC is predicted to affect all levels of biological organisation, from the individual to ecosystem scales. Nonetheless, we know nothing about bacteria-bacteriophage AC in perhaps the most important and clinically relevant microbial ecosystem known to humankind - the human gut microbiome. In this opinion piece I review current research on bacteria-phage AC in in vitro and natural populations of microbes. I then examine the evidence and discuss the potential role of AC in driving observed patterns of intra- and interindividual variation in the gut microbiome together with detailing the potential functional consequences of such AC-driven microbial variation for human health and disease.
1878-4380
10.1016/j.tim.2017.02.012
Grant Details