https://www.readcube.com/articles/10.1186/s12875-018-0853-z?shared_access_token=SkCKKopGLytSVpz7JpSkCG_BpE1tBhCbnbw3BuzI2RN_5moiAX6wvQAfklBz8nwG5_Jaq92RIwlZSC82C7MHxBfci0T8zRrFEio_M1o_aisjqZrw8t6W_DGpI9om0biQr7_ZVdZKwN5tAP5N_58OHbrQQUU2z7icm0nSmXEwsCc%3D