Peer-Reviewed Journal Details
Mandatory Fields
Barry, Alison; Cronin, Owen; Ryan, Aisling M.; Sweeney, Brian; O’Toole, Orna; O’Halloran, Ken D.; Downer, Eric J.
Neurological Sciences
Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis
Optional Fields
Multiple sclerosis Exercise Cytokines Plasma Interleukin-10
The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.
Grant Details