Other Publication Details
Mandatory Fields
Reviews
Paul, G;Sullivan, AM
2019
February
Trophic factors for Parkinson's disease: Where are we and where do we go from here?
Validated
1
WOS: 32 ()
Optional Fields
CONVECTION-ENHANCED DELIVERY NIGROSTRIATAL DOPAMINERGIC SYSTEM GROWTH FACTOR-BB NEUROTROPHIC FACTOR RAT MODEL GENE-TRANSFER INTRAPUTAMENAL INFUSION SUBSTANTIA-NIGRA FUNCTIONAL RECOVERY STRIATAL DELIVERY
Perhaps the most important unmet clinical need in Parkinson's disease (PD) is the development of a therapy that can slow or halt disease progression. Extensive preclinical research has provided evidence for the neurorestorative properties of several growth factors, yet only a few have been evaluated in clinical studies. Attempts to achieve neuroprotection by addressing cell-autonomous mechanisms and targeting dopaminergic neurons have been disappointing. Four different trophic factors have so far entered clinical trials in PD: glial cell line-derived growth factor, its close structural and functional analog neurturin, platelet-derived growth factor and cerebral dopaminergic neurotrophic factor. This article reviews the pre-clinical evidence for the neuroprotective and neurorestorative actions of these growth factors and discusses limitations of preclinical models, which may hamper successful translation to the clinic. We summarize the previous and ongoing clinical trials using growth factors in PD and emphasize the caveats in clinical trial design that may prevent the further development and registration of potentially neuroprotective and neurorestorative treatments for individuals suffering from PD.
HOBOKEN
WILEY
0953-816X
440
452
10.1111/ejn.14102
Grant Details