Peer-Reviewed Journal Details
Mandatory Fields
Hollywood, JA;Sanz, DJ;Davidson, AJ;Harrison, PT
2018
September
Current Stem Cell Reports
Gene Editing of Stem Cells to Model and Treat Disease
Validated
()
Optional Fields
IN-VIVO DNA METHYLATION CRISPR-CAS9 NUCLEASES ICRISPR PLATFORM OPTICAL CONTROL GENOMIC DNA CPG ISLANDS GUIDE RNA CAS9 MOUSE
4
253
263
Purpose of Review The ability to reprogramme any adult cell back into a pluripotent stem cell state coupled with the capability to precisely edit its genomic sequence has given scientists almost unlimited potential to model any genetic disease and holds great promise for regenerative medicine. Recent Findings The discovery of CRISPR/Cas9 coupled with continued development and modification of this system has made it possible to manipulate gene expression at both a genetic and epigenetic level exposing the true power of stem cells. The applications of this technology to model any genetic disease, screen new drugs, generate organs for donation and develop cell therapies appear limitless. Summary In this review, we will provide a SWOT analysis of CRISPR/Cas9 and discuss the most recent developments in induced pluripotent stem cell gene editing and the impact being made in the clinic.
HEIDELBERG
2198-7866
10.1007/s40778-018-0140-x
Grant Details