Peer-Reviewed Journal Details
Mandatory Fields
Kozareva, DA;Hueston, CM;O'Leime, CS;Crotty, S;Dockery, P;Cryan, JF;Nolan, YM
2019
June
Journal of Neuroimmunology
Absence of the neurogenesis-dependent nuclear receptor TLX induces inflammation in the hippocampus
Validated
Optional Fields
NEURAL STEM-CELLS ADULT-BORN NEURONS ALZHEIMERS-DISEASE RAMIFIED MICROGLIA DENTATE GYRUS M2 MICROGLIA BRAIN INTERLEUKIN-1-BETA ACTIVATION ASTROCYTES
331
87
96
The orphan nuclear receptor TLX (Nr2e1) is a key regulator of hippocampal neurogenesis. Impaired adult hippocampal neurogenesis has been reported in neurodegenerative and psychiatric conditions including dementia and stress-related depression. Neuroinflammation is also implicated in the neuropathology of these disorders, and has been shown to negatively affect hippocampal neurogenesis. To investigate a role for TLX in hippocampal neuroinflammation, we assessed microglial activation in the hippocampus of mice with a spontaneous deletion of TLX. Results from our study suggest that a lack of TLX is implicated in deregulation of microglial phenotype and that consequently, the survival and function of newborn cells in the hippocampus is impaired. TLX may be an important target in understanding inflammatory-associated impairments in neurogenesis.
AMSTERDAM
0165-5728
10.1016/j.jneuroim.2017.08.008
Grant Details