Peer-Reviewed Journal Details
Mandatory Fields
Miller, C.M.; O’Sullivan, E.C.; McCarthy, F.O.
2019
June
Pharmaceuticals
Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells
Published
()
Optional Fields
ellipticine; anticancer; heterocyclic chemistry; indole; NCI screen; topoisomerase II
12
2
90
90
Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects
Basel, Switzerland
1424-8247
https://www.mdpi.com/1424-8247/12/2/90
https://doi.org/10.3390/ph12020090
Grant Details
Irish Research Council