Peer-Reviewed Journal Details
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Hyun, C and Lavulo, L and O'Leary, C and Kim, JT;
2006
Isolation and characterization of the canine NKX2-5 gene
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We report the first isolation and characterization of the canine NKX2-5 gene. This canine homologue has high homology in genomic structure and functional domains to other NKX2-5 across a number of different species. Given the critical role of NKX2-5 in cardiac morphogenesis as seen in human and mouse studies of congenital heart defects, the availability of the canine NKX2-5 provides a good starting point for identifying mutations that may be responsible for certain forms of canine congenital heart defects.
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