Howard, Caoimhe; Powell, Anna S.; Pavlidis, Elena; Pavel, Andreea; Finn, Daragh; Allen, Andrew; Olavarria‐Ramirez, Loreto; Clarke, Gerard; Livingstone, Vicki; Boylan, Geraldine B.; Dempsey, Eugene M.

2020

Unknown

Acta Paediatrica

No effect of a musical intervention on stress response to venepuncture in a neonatal population

Published

Altmetric: 10 ()

Cortisol Music intervention Neonatology Intensive-care Heel-lance Premature-infant Procedural pain Preterm Management Efficacy Relief

109

511

517

Aim To investigate the effect of a musical intervention on neonatal stress response to venepuncture as measured by salivary cortisol levels and pain profile scores. Methods In a randomised control crossover trial, participants were randomised to both a control arm (sucrose) and intervention arm (sucrose and music) for routine venepuncture procedures. Salivary swabs were collected at baseline, 20 minutes post-venepuncture and 4 hours post-venepuncture. Pain levels were assessed using the Premature Infant Pain Profile (PIPP). A total of 16 preterm neonates participated in both arms to complete the study. Results Cortisol values were elevated at all timepoints in the intervention arm (baseline, 20 minutes, and 4 hours post-procedure) but not significantly so (P = .056, P = .3, and P = .575, respectively). Median change in cortisol values from baseline was +128.48 pg/mL (-47.66 to 517.02) at 20 minutes and +393.52 pg/mL (47.88-1221.34) at 4 hours post-procedure in the control arm compared to -69.564 pg/mL (-860.96 to 397.289) and +100.48 pg/mL (-560.46 to 842.99) at 20 minutes and 4 hours post-procedure in the intervention arm. There was no statistically significant difference observed between groups (P = .311 at 20 minutes, and P = .203 at 4 hours post-procedure). PIPP scores were not significantly different between study arms. Conclusion Our findings did not support the additional benefit of music intervention on neonatal stress response to venepuncture in preterm infants.

HOBOKEN

0803-5253

10.1111/apa.15018