Peer-Reviewed Journal Details
Mandatory Fields
O'Connell O.;Magee C.;Fitzgerald B.;Burke L.;Plant W.;Plant B.
2010
August
NDT plus
A CF patient with progressive proteinuric renal disease: A CF-specific nodular glomerulosclerosis?
Validated
Scopus: 5 ()
Optional Fields
CF renal disease cystic fibrosis nebulized tobramycin toxicity nodular glomerulosclerosis
3
4
354
356
Cystic fibrosis (CF) is a multisystemic disease but without a classical disease-specific renal phenotype. A 32-year-old male patient with CF (F508/F508) presented with a nephrotic syndrome. Renal biopsy revealed nodular glomerulosclerosis (NGS) occurring in the absence of diabetes mellitus, amyloidosis and any other known common cause of NGS. He had a progressive decline in estimated glomerular filtration rate (eGFR) to chronic kidney disease stage V (eGFR <15 mL/min/1.73 m2) over a 3-year period despite optimal medical management. This is the fourth reported case of NGS in a patient with CF without diabetes and is the first to originate from a European country. This case supports the concept of a CF-related NGS. 2010 The Author.
1753-0784
10.1093/ndtplus/sfq054
Grant Details