Peer-Reviewed Journal Details
Mandatory Fields
Daly, C.,Griffin, E.,Ashcroft, D. M.,Webb, R. T.,Perry, I. J.,Arensman, E.
Clinical Drug Investigation
Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015
Optional Fields
Adult Alcohol Drinking/epidemiology Amines/*poisoning Cyclohexanecarboxylic Acids/*poisoning Drug Overdose/*epidemiology Emergency Service, Hospital/statistics & numerical data Female Gabapentin Hospitalization/statistics & numerical data Humans Ireland/epidemiology Male Middle Aged Pregabalin/*poisoning Registries/statistics & numerical data Young Adult gamma-Aminobutyric Acid/*poisoning
INTRODUCTION: Intentional drug overdose (IDO) is a significant public health problem. Concerns about the misuse of gabapentinoids, i.e. pregabalin and gabapentin, including their consumption in IDO have grown in recent years. This paper examines the trends in the prevalence of gabapentinoids taken in IDO, the profile of individuals taking them, and associated overdose characteristics. METHODS: Presentations to emergency departments involving IDO, recorded by the National Self-Harm Registry Ireland between 1 January 2007 and 31 December 2015 were examined. Data items included patient demographics, drug names, total tablet quantity consumed and alcohol involvement. RESULTS: Gabapentinoids were involved in 2115 (2.9%) of the 72,391 IDOs recorded. Presentations involving a gabapentinoid increased proportionally from 0.5% in 2007 to 5.5% in 2015. The majority of IDOs involving a gabapentinoid were made by females (59.9%), with over one-third (37.2%) involving alcohol. Compared with IDOs involving other drugs, presentations with a gabapentinoid were made by persons who were older (median 37 vs. 32 years) and involved a significantly greater median quantity of tablets (30 vs. 21, p
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