Peer-Reviewed Journal Details
Mandatory Fields
Ellis J.;Ross R.;Hill C.
2020
January
Future Microbiology
Nisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteria
Validated
WOS: 13 ()
Optional Fields
antibiotics antimicrobial bacteriocins lacticin 3147 methicillin nisin z pathogen penicillin synergy vancomycin
14
18
1573
1587
2020 Colin Hill. Aim: To determine if bacteriocins improve antibiotic efficacy. Materials & methods: Deferred antagonism assays identified bacteriocins with activity. Growth curves and time kill assays demonstrated bactericidal activity of antimicrobial combinations, and checkerboard assays confirmed synergy. Methicillin-resistant Staphylococcus aureus-infected porcine skin model determined ex vivo efficacy. Results: Subinhibitory concentrations of lacticin with penicillin or vancomycin resulted in complete growth inhibition of strains and the improved inhibitory effect was apparent after 1 h. Nisin with methicillin proved more effective against methicillin-resistant Staphylococcus aureus than either antimicrobial alone, revealing partial synergy and significantly reduced pathogen numbers on porcine skin after 3 h compared with minimal inhibition for either antimicrobial alone. Conclusion: Nisin Z and lacticin 3147 may support the use of certain antibiotics and revive ineffective antibiotics.
1746-0913
10.2217/fmb-2019-0153
Grant Details