Other Publication Details
Mandatory Fields
Reviews
Barrett M.;Hand C.K.;Shanahan F.;Murphy T.;O'Toole P.W.
2020
January
Mutagenesis by Microbe: the Role of the Microbiota in Shaping the Cancer Genome
Validated
1
Optional Fields
DNA damage microbiome microbiota mutational mechanism mutational signatures
2020 Elsevier Inc. Cancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes collectively known as the microbiota. The microbiota plays a role in altering the tumor microenvironment and proliferation. In addition, microbes have been shown to elicit DNA damage which provides the driver for somatic mutations. An understanding of microbiota-driven mutational mechanisms would contribute to a more complete understanding of the origins of the cancer genome. Here, we review the modes by which microbes stimulate DNA damage and the effect of these phenomena upon the cancer genomic architecture, specifically in the form of mutational spectra and mutational signatures.
2405-8033
10.1016/j.trecan.2020.01.019
Grant Details