Peer-Reviewed Journal Details
Mandatory Fields
Duffy, C. F.,Killeen, G. F.,Connolly, C. D.,Power, R. F.
Journal of Agricultural and Food Chemistry
Effects of Dietary Supplementation with Yucca schidigera Roezl ex Ortgies and Its Saponin and Non-saponin Fractions on Rat Metabolism
Optional Fields
Yucca schidigera Roezl ex Ortgies, family Lillaceae, was fractionated with butan-1-ol to yield a butanol extractable fraction (BE; saponin fraction) and a non-butanol fraction (NBE; non-saponin fraction). Four groups of eight male rats were allowed ad libitum access to diets supplemented with water (control) or 200 mg kg(-)(1) total Y. schidigera (TOT) or 200 mg kg(-)(1) of each of the fractions (NBE or BE). The effects of dietary supplementation with the fractions and their interactions in TOT were analyzed according to the factorial experimental design by two-way analysis of variance. All three supplementation groups displayed significantly reduced serum urea levels (P < 0.05). The TOT and NBE fractions were found to significantly increase serum insulin levels (P < 0.01) in the absence of any fluctuations in serum glucose levels. Urea cycle enzyme activities, namely, arginase (EC and argininosuccinate lyase (EC, were significantly decreased (P < 0.05) in vivo, although no effect was observed in vitro. Both fractions displayed effects, indicating that the active constituents are present in both fractions.
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