Dickinson, Michael G and Kowalski, Piotr S and Bartelds, Beatrijs and Borgdorff, Marinus and Feen, Diederik van der and Sietsma, Hannie and Molema, Grietje and Kamps, Jan and Berger, Rolf

2014

January

Cardiovascular Research

A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension

Validated

Altmetric: 2 ()

103

4

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584

Pulmonary arterial hypertension (PAH) is characterized by the development of unique neointimal lesions in the small pulmonary arteries, leading to increased right ventricular (RV) afterload and failure. Novel therapeutic strategies are needed that target these neointimal lesions. Recently, the transcription factor Egr-1 (early growth response protein 1) was demonstrated to be up-regulated early in experimental neointimal PAH. Its effect on disease development, however, is unknown. We aimed to uncover a novel role for Egr-1 as a molecular inductor for disease development in PAH.

10.1093/cvr/cvu169