Peer-Reviewed Journal Details
Mandatory Fields
McKee M.L.;Zheng L.;O’sullivan E.C.;Kehoe R.A.;Doyle Prestwich B.M.;Mackrill J.J.;McCarthy F.O.
2020
July
Journal of Pathogens
Synthesis and evaluation of novel ellipticines and derivatives as inhibitors of Phytophthora infestans
Validated
Optional Fields
Ellipticinium salts Isoellipticines Mycelial growth Oomycete Phytophthora infestans Zoosporogenesis
9
7
1
23
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The pathogen Phytophthora infestans is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance. Current strategies for crop treatment are inadequate with limitations of efficacy and market alternatives. Ellipticines have recently been reported to have fungicidal properties and have been assessed against P. infestans growth with promising results. We hereby report a probe of the ellipticine framework to investigate the alkyl subunit and screen a set ellipticines and derivatives to identify new lead compounds to act against P. infestans. A series of ellipticinium salt derivatives have been identified with exceptional growth inhibitory activity and apparent lack of toxicity towards a human cell-line surpassing the effect of known and marketed fungicides. This report identifies the potential of this natural product derivative as a novel fungicide.
2076-0817
10.3390/pathogens9070558
Grant Details