Other Publication Details
Mandatory Fields
Reviews
Brugere, JF;Atkins, JF;O'Toole, PW;Borrel, G
2018
December
Pyrrolysine in archaea: a 22nd amino acid encoded through a genetic code expansion
Validated
1
WOS: 6 ()
Optional Fields
The 22nd amino acid discovered to be directly encoded, pyrrolysine, is specified by UAG. Until recently, pyrrolysine was only known to be present in archaea from a methanogenic lineage (Methanosarcinales), where it is important in enzymes catalysing anoxic methylamines metabolism, and a few anaerobic bacteria. Relatively new discoveries have revealed wider presence in archaea, deepened functional understanding, shown remarkable carbon source-dependent expression of expanded decoding and extended exploitation of the pyrrolysine machinery for synthetic code expansion. At the same time, other studies have shown the presence of pyrrolysine-containing archaea in the human gut and this has prompted health considerations. The article reviews our knowledge of this fascinating exception to the `standard' genetic code.
LONDON
PORTLAND PRESS LTD
2397-8554
607
618
10.1042/ETLS20180094
Grant Details