Peer-Reviewed Journal Details
Mandatory Fields
Mackey, K;Jones, DJ;Pardo, LM;McGlacken, GP
2021
January
European Journal of Organic Chemistry
Quinoline Ligands Improve the Classic Direct C-H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans
Validated
WOS: 1 ()
Optional Fields
INTRAMOLECULAR DIRECT ARYLATION ELECTRON-DEFICIENT ARENES BOND FUNCTIONALIZATION PALLADIUM ACTIVATION CATALYSTS 2-PYRONES ACIDS CONSTRUCTION OXYGENATION
The C-H functionalisation approach to the synthesis of dibenzofurans is hampered by a number of problems. Herein we describe the evolution of a cheap, bench stable quinoline ligand, which obviates most of the current limitations and allows for a high yielding synthesis of a range of valuable dibenzofurans. Dibenzofurans are important motifs in natural products and compounds with wide biological activity.
WEINHEIM
1434-193X
10.1002/ejoc.202001416
Grant Details