Peer-Reviewed Journal Details
Mandatory Fields
Noel, B and Krayenbuhl, B and Cerottini, JP and Guggisberg, D and Buxtorf, K and Pires, A and Panizzon, RG;
Thromboangiitis obliterans: A rare cause of a reversible Raynaud's phenomenon
Optional Fields
A 25-year-old woman with progressive Raynaud's phenomenon and digital necrosis is presented. Systemic sclerosis and other connective tissue disorders as well as atherosclerosis and arterial emboli were excluded with appropriate laboratory examinations. Arteriography revealed multiple palmar and digital occlusions with corkscrew-shaped vessels. Based on these characteristic arteriographic and clinical findings, the diagnosis of thromboangiitis obliterans was finally retained, With intravenous perfusion of the prostacyclin analogue iloprost (2 ng/kg/min, 6 h daily during 21 days), a complete healing of Raynaud's phenomenon and of the digital necrosis was observed. There was no recurrence during the 1-year follow-up. This observation demonstrates that thromboangiitis obliterans is a potential reversible cause of severe Raynaud's phenomenon in young women even in the absence of lower limb involvement. Early recognition is important to avoid irreversible complications such as loss of digits. Copyright (C) 2000 S. Karger AG, Basel.
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