Peer-Reviewed Journal Details
Mandatory Fields
Aury, Jean-Marc and Jaillon, Olivier and Duret, Laurent and Noel, Benjamin and Jubin, Claire and Porcel, Betina M. and Segurens, Beatrice and Daubin, Vincent and Anthouard, Veronique and Aiach, Nathalie and Arnaiz, Olivier and Billaut, Alain and Beisson, Janine and Blanc, Isabelle and Bouhouche, Khaled and Camara, Francisco and Duharcourt, Sandra and Guigo, Roderic and Gogendeau, Delphine and Katinka, Michael and Keller, Anne-Marie and Kissmehl, Roland and Klotz, Catherine and Koll, France and Le Mouel, Anne and Lepere, Gersende and Malinsky, Sophie and Nowacki, Mariusz and Nowak, Jacek K. and Plattner, Helmut and Poulain, Julie and Ruiz, Francoise and Serrano, Vincent and Zagulski, Marek and Dessen, Philippe and Betermier, Mireille and Weissenbach, Jean and Scarpelli, Claude and Schaecht;
2006
November
Nature
Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia
Validated
Optional Fields
444
7116
171
178
The duplication of entire genomes has long been recognized as having great potential for evolutionary novelties, but the mechanisms underlying their resolution through gene loss are poorly understood. Here we show that in the unicellular eukaryote Paramecium tetraurelia, a ciliate, most of the nearly 40,000 genes arose through at least three successive whole-genome duplications. Phylogenetic analysis indicates that the most recent duplication coincides with an explosion of speciation events that gave rise to the P. aurelia complex of 15 sibling species. We observed that gene loss occurs over a long timescale, not as an initial massive event. Genes from the same metabolic pathway or protein complex have common patterns of gene loss, and highly expressed genes are over-retained after all duplications. The conclusion of this analysis is that many genes are maintained after whole-genome duplication not because of functional innovation but because of gene dosage constraints.
10.1038/nature05230
Grant Details