Peer-Reviewed Journal Details
Mandatory Fields
Eccles, Kevin S.,Elcoate, Curtis J.,Stokes, Stephen P.,Maguire, Anita R.,Lawrence, Simon E.;
2010
October
Crystal Growth & Design
Sulfoxides: Potent Co-Crystal Formers
Validated
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Optional Fields
10
10
4243
4245

The design of co-crystals requires knowledge of robust supramol. synthons. The sulfoxide is a potent H bond acceptor and was used as a co-crystal former with a range of NH functional groups, via N-HO=S H bonds. The NH functional group retains favorable H bond motifs from its own structure in all cases where this is possible, with the sulfoxide interacting in a discrete, capping fashion in four cases and in a bifurcated, bridging fashion in the three other cases presented here. Crystallog. data are given for 7 co-formers, dibenzyl sulfoxide and cyclohexanecarbothioamide.

1528-7483
Grant Details