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Mandatory Fields
Zou, Yifang; Xiao, Fang; Song, Liu; Sun, Bingxue; Sun, Dandan; Chu, Di; Wang, Limei; Han, Shulan; Yu, Zhuo; O'Driscoll, Caitriona M.; Guo, Jianfeng
International Journal of Pharmaceutics
A folate-targeted PEGylated cyclodextrin-based nanoformulation achieves co-delivery of docetaxel and siRNA for colorectal cancer.
WOS: 8 ()
Optional Fields
Colorectal cancer Nanoparticle Chemotherapy Gene therapy Combination therapy
Docetaxel (DTX) is a chemotherapeutic agent used for a range of cancers, but it has little activity against colorectal cancer (CRC). However, combination therapy with other therapeutic agents is a potential strategy to enhance the efficacy of DTX in CRC treatment. The nuclear factor-żB (NF-żB) signaling pathway is implicated in a variety of malignancies (e.g., CRC), and the blockade of NF-żB may increase the sensitivity of cancer cells to chemotherapy. The application of small interference RNA (siRNA) to inhibit the translation of complementary mRNA has demonstrated the potential for cancer gene therapy. In this study, an amphiphilic cationic cyclodextrin (CD) nanoparticle modified with PEGylated folate (FA; a ligand to target folate receptor on CRC) has been developed for co-delivery of DTX and siRNA (against the RelA, a subunit of NF-żB) in the treatment of CRC. The resultant co-formulation (CD.DTX.siRelA.PEG-FA) achieved cell-specific uptake indicating the function of the folate targeting ligand. The CD.DTX.siRelA.PEG-FA nanoparticle enhanced the apoptotic effect of DTX with the downregulation of RelA expression, which significantly retarded the growth of CRC in mice, without causing significant toxicity. These results suggest that the FA-targeted PEGylated CD-based co-formulation provides a promising strategy for combining DTX and siRNA in treating CRC.
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