Peer-Reviewed Journal Details
Mandatory Fields
Stockdale, SR;Hill, C
2021
December
Current Opinion In Virology
Progress and prospects of the healthy human gut virome
Validated
WOS: 2 ()
Optional Fields
BACTERIAL MICROBIOME BACTERIOPHAGE PHAGE DYNAMICS VIRUS
51
164
171
Not all viruses associated with humans cause disease. Nonpathogenic human-infecting viruses are predicted as important for immune system induction and preparation. Phages that infect bacteria are the most abundant predators of the human microbial ecosystem, promoting and maintaining bacterial diversity. Metagenomic analyses of the human gut virome and microbiome are unravelling the intricate predator-prey dynamics of phage-bacteria co-existence, co-evolution, and their interplay with the human host. While most adults harbour a distinctly individualistic and persistent community of virulent phages, new-borns are dominated by temperate phages heavily influenced by environmental exposures. The future development of microbiome-based interventions, therapeutics, and manipulation, will require a greater understanding of the human microbiome and the virome.
OXFORD
1879-6257
10.1016/j.coviro.2021.10.001
Grant Details