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Mandatory Fields
Reviews
DeLaGarza-Pineda, O;Mailo, JA;Boylan, G;Chau, V;Glass, HC;Mathur, AM;Shellhaas, RA;Soul, JS;Wusthoff, CJ;Chang, T
2021
August
Management of seizures in neonates with neonatal encephalopathy treated with hypothermia
Validated
1
WOS: 1 ()
Optional Fields
HYPOXIC-ISCHEMIC ENCEPHALOPATHY BRAIN-INJURY ELECTROGRAPHIC SEIZURES STATUS EPILEPTICUS TERM INFANTS RISK-FACTORS FULL-TERM MULTICENTER EPILEPSY NEWBORNS
Neonatal encephalopathy (NE) is the most common etiology of acute neonatal seizures - about half of neonates treated with therapeutic hypothermia for NE have EEG-confirmed seizures. These seizures are best identified with continuous EEG monitoring, as clinical diagnosis leads to under-diagnosis of subclinical seizures and overtreatment of events that are not seizures. High seizure burden, especially status epilepticus, is thought to augment brain injury. Treatment, therefore, is aimed at minimizing seizure burden. Phenobarbital remains the mainstay of treatment, as it is more effective than levetiracetam and easier to administer than fosphenytoin. Emerging evidence suggests that, for many neonates, it is safe to discontinue the phenobarbital after acute seizures resolve and prior to hospital discharge.
OXFORD
ELSEVIER SCI LTD
1744-165X
10.1016/j.siny.2021.101279
Grant Details