Peer-Reviewed Journal Details
Mandatory Fields
McCarthy FO, Chopra J, Ford A, Hogan SA, Kerry JP, O'Brien NM, Ryan E, Maguire AR;
2005
August
Organic & Biomolecular Chemistry
Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives.
Validated
Optional Fields
3
16
3059
3065
Beta-sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.
10.1039/b505069c
Grant Details