Peer-Reviewed Journal Details
Mandatory Fields
Kearney, Aoife M.; Lynch, Dennis; Collins, Stuart G.; Maguire, Anita R.
2021
October
Tetrahedron Letters
Telescoped diazo transfer and rhodium-catalysed S-H insertion in continuous flow
Published
WOS: 2 ()
Optional Fields
Diazo transfer α-Diazolactams SH insertion Telescoped continuous processes Rhodium carboxylate catalyst Taming hazardous chemistry Trifluoromethanesulfonyl azide Alpha-sulfonyl Triflyl azide Safe Generation Efficient Reagent
83
153438
Rhodium-catalysed S-H insertion of alpha-diazo-gamma-butyrolactams has been successfully telescoped using continuous processing with in situ generated triflyl azide in flow and deacylative diazo transfer, incorporating real-time reaction monitoring of the final process outflow by IR spectroscopy. Significantly, the alpha-diazo-gamma-butyrolactam reaction stream was sufficiently pure to progress to the rhodium-catalysed S-H insertion step without detrimental impact on the rhodium catalyst or the reaction efficiency. (C) 2021 The Author(s). Published by Elsevier Ltd.
OXFORD
0040-4039
10.1016/j.tetlet.2021.153438
Grant Details